Often yes, but check five items before ordering: the rectifier’s charge profile and whether it has a selectable lithium setting; the DC bus window against a roughly 44–58 V lithium range; LVD and BMS coordination, setting the plant LVD above the BMS cut-off so load shedding happens before the battery disconnects itself; communications compatibility, remembering that the same connector does not mean the same protocol; and whether the rectifier manufacturer supports third-party lithium in their plant. This is the highest-value question in the vertical and almost every answer online is written for a recreational vehicle. /can-you-replace-vrla-with-lithium-in-a-48v-dc-power-system/